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Sophia Karandashova

Sophia Karandashova

Education:

Oregon State University, Honors B.S. in Microbiology 2008
Stephen F. Austin State University, M.S. in Biotechnology 2010
Hometown: Moscow, Russia
Thesis Adviser: Judith Voynow, MD; CCTR (Cancer and Molecular Medicine)

Research interests:

Sophia’s main research interests are microbiology and pulmonary disease. In particular, Sophia is passionate about translational applications of basic research, and enjoys working with animal models. Her master’s thesis focused on enhancing a rabbit model of complex pleural injury by expressing human proteins associated with the fibrinolytic system (in particular, human plasminogen activator inhibitor-1), in an attempt to manipulate fibrin turnover in the pleural space. This model is designed to further the development of novel molecular-targeting therapies for clearing pleural loculations that could be possible alternatives to surgery.

Personal bio:

Sophia was born in Moscow, Russia and immigrated to the U.S. when she was eight, eventually moving to Richmond, where she lived until leaving for college. After graduating from OSU and earning a master’s at SFASU, she worked as a research associate for the UT Health Science Center in Tyler, Texas in a lab that focuses on pulmonary and pleural diseases. She has a wide variety of interests, from ballroom dancing to skiing. She especially enjoys writing and reading fiction. She’s very happy to be back on the East Coast, and is enjoying rediscovering Richmond.

Publications:

  • Florova G, Azghani A, Karandashova S, Schaefer C, Koenig K, Stewart-Evans K, Declerck PJ, Idell S, Komissarov AA. “Targeting of Plasminogen Activator Inhibitor 1 Improves Fibrinolytic Therapy for Tetracycline Induced Pleural Injury in Rabbits.” Am J Respir Cell Mol Biol. 2014 Aug 20. [Epub ahead of print]

  • Seidman D, Ojogun N, Walker NJ, Mastronunzio JE, Kahlon A, Hebert K, Karandashova S, Miller D, Tegels B, Marconi R, Fikrig E, Borjesson D, Carlyon JA. “Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells” Cell Microbiol. 2014 Aug;16(8):1133-45.
  • Florova G, Karandashova S, Declerck PJ, Idell S, Komissarov AA. “Remarkable Stabilization of Plasminogen Activator Inhibitor 1 in a "Molecular Sandwich" Complex.” Biochemistry. 2013 Jul 9;52(27):4697-709.
  • Komissarov AA, Florova G, Azghani A, Karandashova S, Kurdowska AK, Idell S. “Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids.” Am. J. Physiol. Lung Cell Mol. Physiol., Nov. 2013; 305(10): L682-92.
  • Karandashova S, Florova G, Azghani AO, Komissarov AA, Koenig K, Tucker TA, Allen TC, Stewart K, Tvinnereim A, Idell S. “Adenovirus-mediated delivery of active human PAI-1 into the pleural space exacerbates tetracycline-induced pleural injury in rabbits.” Am. J. Respir. Cell Mol. Biol., Jan. 2013; 48(1): 44-52.
  • Sophia Karandashova, Galina Florova, Torry Tucker, Ali Azghani, Andrey Komissarov, Timothy Allen, Kris Stewart, , Amy Tvinnereim, Kathy Koenig, and Seven Idell. "Adenovirus-mediated delivery of active human PAI-1 into the pleural space exacerbates tetracycline-induced pleural injury in rabbits." Am. J. Respir. Cell Mol Biol, Under Review.

  • Andrey Komissarov, Galina Florova, Ali Azghani, Sophia Karandashova, Kris Stewart, Amy Tvinnereim, Paul Declerck, and Steven Idell. "Plasminogen Activator Inhibitor 1 Targeting Interventions In The Treatment Of Rabbits With Tetracycline-Induced Pleurodesis." Presented at the American Thoracic Society International Conference in May 2012.

  • Andrey Komissarov, Galina Florova, Ali Azghani, Sophia Karandashova, and Seven Idell. "High Levels Of Extracelular DNA In Pleural Fluids Of Animals And Patients With Empyema Suppress Fibrinolysis." Presented at the American Thoracic Society International Conference in May 2012.

  • Sophia Karandashova, Galina Florova, Torry Tucker, Ali Azghani, Timothy Allen, Kris Stewart, Andrey Komissarov, Amy Tvinnereim, Kathy Koenig, and Seven Idell. "Adenovirus-Mediated Delivery Of High Levels Of Plasminogen Activator Inhibitor 1 Activity To The Pleural Space Exacerbates Fibrotic Injury In Rabbits With Tetracycline-Induced Pleural Injury." Am. J. Respir. Crit. Care Med., May 2011; 183: A2367.

  • Andrey Komissarov, Galina Florova, Ali Azghani, Sophia Karandashova, Kris Stewart, and Seven Idell. "Single Chain Urokinase Yields Relatively Low Grade Fibrinolytic Activity And As More Bioavailable Than Tissue Type Plasminogen Activator In Pleural Fluids Of Rabbits With Tetracycline-Induced Pleurodesis." Am. J. Respir. Crit. Care Med., May 2011; 183: A2366.

  • Andrey Komissarov, Galina Florova, Ali Azghani, Sophia Karandashova, Kris Stewart, Andrew Mazar, and Seven Idell. "Active Urokinase Is Protected In Vitro And In Tetracycline-induced Pleural Injury In Rabbits By An Inactive Ser195Ala Mutant." Am. J. Respir. Crit. Care Med., May 2010; 181: A4356.