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Tim Kegelman

Tim Kegelman


University of Notre Dame, B.S. in Chemical Engineering 2007
Hometown: Yorktown, Va.
Thesis adviser: Paul B. Fisher, Ph.D., human and molecular genetics

Research interests:

The goal of Tim’s research is to advance the field of cancer therapeutics. His lab uses discoveries in cancer molecular genetics to develop new treatments that halt or reverse tumor progression. His research focuses on mda-9/syntenin's role in nervous system tumors and as a target for therapy. He sees his future clinical and research interests in pediatrics, focusing on oncology or genetic disease.

Personal bio:

Tim grew up in Virginia, graduated from Tabb High School, and returned to Virginia after college. At Notre Dame, he was the captain of the men's swim team and competed at the NCAA championships. He has found that Richmond has something for everyone and has been impressed with the parks and outdoor events.


  • Das SK, Bhutia SK, Kegelman TP, Peachy L, Oyesanya RA, Dasgupta S, Sokhi UK, Azab B, Dash R, Quinn BA, Kim K, Barral PM, Su ZZ, Boukerche H, Sarkar D, Fisher PB. MDA-9/syntenin: a positive gatekeeper of melanoma metastasis. Front Biosci. 2012

  • Bhutia SK, Das SK, Kegelman TP, Azab B, Dash R, Su ZZ, Wang XY, Rizzi F, Bettuzzi S, Lee SG, Dent P, Grant S, Curiel DT, Sarkar D, Fisher PB. mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer. J Cell Physiol. 2012

  • Lee SG, Kim K, Kegelman TP, Dash R, Das SK, Choi JK, Emdad L, Howlett EL, Jeon HY, Su ZZ, Yoo BK, Sarkar D, Kim SH, Kang DC, Fisher PB. Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity. Cancer Res. 2011

  • Kim K, Lee SG, Kegelman TP, Su ZZ, Das SK, Dash R, Dasgupta S, Barral PM, Hedvat M, Diaz P, Reed JC, Stebbins JL, Pellecchia M, Sarkar D, Fisher PB. Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol. 2011

  • Bhutia SK, Kegelman TP, Das SK, Azab B, Su ZZ, Lee SG, Sarkar D, Fisher PB. Astrocyte elevated gene-1 activates AMPK in response to cellular metabolic stress and promotes protective autophagy. Autophagy. 2011

  • Bhutia SK, Kegelman TP, Das SK, Azab B, Su ZZ, Lee SG, Sarkar D, Fisher PB. Astrocyte elevated gene-1 induces protective autophagy. Proc Natl Acad Sci USA. 2010