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Sheela Damle

Sheela DamleEducation:

Cornell University, B.S. in Chemical Engineering (2008)
Hometown: Grand Forks, ND
PhD Advisor: Dan Conrad, PhD
Graduate Program: Microbiology and Immunology

 

Research Interests:

Sheela’s research background is in orthopedic research, specifically cartilage and intervertebral disc biology and tissue engineering. She worked at New York City’s Hospital for Special Surgery, developing a new minimally-invasive anterior spine fusion. Although she found orthopedic research interesting, she plans to focus on immunology in the future.

Personal Bio:

Sheela was born in Fargo, ND, and was raised in both Fargo and Grand Forks, ND. Apart from academics, Sheela enjoys tennis and volleyball — both of which she has been playing since she was young. She has competed in local, regional, and national tennis tournaments during her MD-PhD training. She also likes to explore the great outdoors via hiking and backpacking.

Honors, Awards, and Grants:

Ruth L. Kirschstein National Research Service Award Individual Predoctoral MD/PhD Fellowship (F30): NIH National Cancer Institute (2015 – 2019)
Chrysalis Project participant: American Academy of Allergy, Asthma, and Immunology (2017)
Phi Kappa Phi Scholarly Achievement Award: VCU School of Medicine, Richmond, VA (2016)
Alpha Epsilon Lambda Honor Society: VCU School of Medicine, Richmond, VA (2016)
Pathology Honor Society: VCU School of Medicine, Richmond, VA (2013)
Alpha Omega Alpha Honor Society: VCU School of Medicine, Richmond, VA (2013)

Professional, Leadership, and Service Activities:

American Academy of Allergy, Asthma, and Immunology
American Association of Immunologists
Medical Society of Virginia

Publications:

Martin, R.K.†, Damle, S.R.†, Zellner, M.P., James, B.N., Valentine, Y.A., Luker, A.J., Lownik, J.C., DeMeules, M.M., Khandjian, L.M., Urban, J.F., and Conrad, D.H. B1 cell IgE impedes B2 cell IgE-mediated mast cell degranulation and parasite expulsion. Cell Reports (Accepted with revisions Aug 2017).

Lownik, J.C.†, Luker, A.J.†, Damle, S.R., Folgosa-Cooley, L.E., El Sayed, R., Hutloff, A., Pitzalis, C., Martin, R.K., El Shikh, M.E., and Conrad, D.H. ADAM10-mediated ICOSL Shedding is Necessary for Proper ICOS Regulation and T cell Responses. Journal of Immunology. (Accepted July 2017).

Damle, S.R., Martin, R.K., Cockburn, C.L., Lownik, J.C., Carlyon, J.A., Smith, A.D., and Conrad, D.H. Notch1 and ADAM10 on murine dendritic cells control the development of type 2 immune responses and IgE production. Allergy. (Accepted July 2017).
Terracina, K. P.; Graham, L. J.; Payne, K. K.; Manjili, M. H.; Baek, A.; Damle, S. R.; Bear, H. D. DNA Methyltransferase Inhibition Increases Efficacy of Adoptive Cellular Immunotherapy of Murine Breast Cancer. Cancer Immunology, Immunotherapy 2016, 65, 1061–1073.

Damle, S.R.†, Martin, R.K.†, Cross, J.V., and Conrad, D.H. Macrophage migration inhibitory factor (MIF) deficiency enhances immune response to Nippostrongylus brasiliensis. Mucosal Immunol. 2016 Apr 6: 10.1038/mi.2016.29.

Martin, R. K., Saleem, S. J., Folgosa, L., Zellner, H. B., Damle, S. R., Nguyen, G.-K. T., Ryan, J.J., Bear, H.D., Irani, A.M., and Conrad, D. H. (2014). Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells. Journal of Leukocyte Biology, 96(July), 1–9. doi:10.1189/jlb.5A1213-644R.

Damle, S. R., Rawlins, B. a., Boachie-Adjei, O., Crystal, R. G., Hidaka, C., & Cunningham, M. E. (2013). Lumbar Spine Intervertebral Disc Gene Delivery: A Pilot Study in Lewis Rats. HSS Journal ®, 9(1), 36–41. doi:10.1007/s11420-012-9319-3.

Damle, S. R., Krzyzanowska, A., Frawley, R. J., & Cunningham, M. E. (2013). Surgical anatomy, transperitoneal approach, and early postoperative complications of a ventral lumbar spine surgical model in Lewis rats. Comparative Medicine, 63(5), 409–15. http://www.ncbi.nlm.nih.gov/pubmed/24210017.

Masahiko, T., Damle, S., Penmatsa, M., West, P., Yang, X., Bostrom, M., Hidaka, C., Yamauchi, M., and Pleshko, N. (2012). Temporal changes in collagen cross-links in spontaneous articular cartilage repair. Cartilage, 3(3), 278–287. doi:10.1177/1947603512437736.

Abstracts, Posters, and Presentations:

Damle, S.R., Martin, R.K., Cockburn, C.L., Lownik, J.C., Carlyon, J.A., Smith, A.D., and Conrad, D.H. Dendritic cell expressed ADAM10: a novel target for reducing Th2 immune responses. Oral presentation at International Congress on Immunology. 2016 Aug 21-26; Melbourne, Australia.

Damle, S.R., Martin, R.K., Cockburn, C.L., Lownik, J.C., Carlyon, J.A., Smith, A.D., and Conrad, D.H. Loss of A Disintegrin And Metalloproteinase 10 (ADAM10) in dendritic cells strongly dampens type 2 immune responses and IgE production. Oral presentation at FASEB IgE and Allergy: 50 Years and Onward. 2016 Jul 24-29; West Palm Beach, FL.

Damle, S.R., Martin, R.K., Cross, J.V., and Conrad, D.H. Deficiency of macrophage migration inhibitory protein enhances clearance of Nippostrongylus brasiliensis. Poster presented at Multifaceted Roles of Th2 Immunity. 2014 Dec 10-12; Bruges, Belgium.